Efficacy of Aromatase Inhibitors for Azoospermia Caused by AZFc Microdeletion: A Cross-Sectional Descriptive Research Study in Chinese Population

Background. Aromatase inhibitors (AIs) can significantly improve semen parameters in infertile men. In this study, we investigated the efficacy of AIs for azoospermia a Chinese population with AZFc microdeletion. Aims. Patients microdeletion who were treated analyzed retrospectively by collecting clinical data, including their hormone profile and treatment outcome. divided into those sperm after AI (group A) without B). Results. The rate Y chromosome AZF microdeletions was 9.30% (313/3364) from March 2015 to 2021, among which patients complete accounted 63.2% (198/313), 198 microdeletion, 69.7% (138/198) showed azoospermia. Forty-six (33.3%) azoospermic had administration. Testosterone (T) testosterone-to-estradiol ratio (T/E2) levels higher group A than B treatment, differences significant (T, P = 0.038 ; T/E2, id="M2"> 0.004 ). Paired id="M3"> t -test demonstrated that change T before statistically ( id="M4"> 0.003 increased E2 T/E2 not id="M5"> 0.057 0.080), but they close threshold value id="M6"> 0.05 Conclusions. largest proportion male infertility caused microdeletions. promote spermatogenesis could be found some used as biomarkers distinguish responded better did respond well.